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Antidepressant medications can take up to several weeks to be fully effective.Early signs that the medication is working include improved sleep, appetite and energy. We all experience depression and anxiety at some level, and because of this, severe problems are sometimes trivialized.The first drug in the SSRI class was Prozac (Fluoxetine), which hit the United States market in 1987. Luvox (Fluvoxamine maleate) was the next SSRI FDA approved in December 05, 1994.However, now its marketing status is "Discontinued".Taking trazodone is not advisable if high blood pressure, Interacts with warfarin (Coumadin) and many herbal supplements.

Amitriptyline is also useful for the treatment of eating disorders, post-herpetic neuralgia, and prevents migraine headaches.The SSRIs represent the first rationally designed class of psychotropic medications.The strategy behind rational drug development is to design a new drug that is capable of affecting a specific neural site of action (eg, uptake pumps, receptors) while avoiding effects on other site of actions.These medications help many people with mental health problems.However, they don’t work for everyone, and even when they do work well, they can only do so much.Physicians use tricyclic antidepressants in the treatment of panic disorder, PTSD, generalized anxiety and depression that occurs with anxiety. If uncomfortable side effects appear, one approach is to wait two to three weeks for them to diminish before increasing to the next higher dose. The sedating side effects can limit productivity and concentration during the day.

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